St. Lawrence Egoji Teachers’ College was founded in 1959 by the then Bishop of the Catholic Diocese of Meru His Lordship Rt. Rev. Fr. Lawrence Victor Bessone and Rev. Fr. La – Greca who was the first principal and chaplain. It was initially started at Muthara in the current Tigania East sub-county and then later relocated to Igoji Division in Imenti South sub-county, 30 kilometres south of Meru town along Embu- Meru highway. Soon after its inception, the college admitted the first twenty-five (25) P 3 teacher trainees. In 1966, the government took over the running of the college and introduced the P1 and P2 courses. The P2 and P3 courses were phased out in 1998.   From 1967 to 1991 the college benefited from phase I, II, III, IV and V of physical development initiated and funded by International Development Agency (I.D.A). Thereafter there were more remarkable infrastructural development initiated by the board of management.

In the year 2020, the government of Kenya phased out Primary Teacher Education (PTE) certificate and Early Childhood Development Education (ECDE) courses and replaced them with Diploma in Primary Teacher Education (DPTE) , Upgrade in Diploma in Primary Teacher Education (UDPTE) and Diploma in Early Childhood Teacher Education (DECTE).

In 2021, the college admitted fifty-seven (57) DPTE, two hundred and ninety-seven (297) UDPTE and one hundred and twenty-three (123) DECTE teacher trainee.

The college is managed by Board of Management, which derives its mandate from the Ministry of Education; to train quality Diploma Teachers in Competency Based Teacher Education Curriculum.